GENERAL CHARACTERISTICS OF TRANSFORMED CELLS.

GENERAL CHARACTERISTICS OF TRANSFORMED CELLS.

GENETEIC CHARACTERS

  • Aneuploid
  • Hetroploid
  • High spontaneous mutation rate
  • Overexpressed oncogenes
  • Mutated or deleted suppressor genes.

STRUCTURAL CHARACTERS

  • Altered cytoskeleton
  • Changed extracellular matrix
  • Modified expression of cell adhesion molecules
  • Disrupted cell polarity

GROWTH CHARACTERS

  • Immortalized cells
  • Loss of contact inhibition
  • Anchorage independent
  • Density limitation of growth reduced
  • Growth factor independent
  • Low serum requirement
  • Shorter population doubling time

NEOPLASTIC CHARACTER

  • Tumorigenic
  • Invasive
  • Increased protease secretion.